Investigation of Proposed Activity of Clarithromycin at GABA(A) Receptors Using [(11)C]Flumazenil PET

[Image: see text] Clarithromycin is a potential treatment for hypersomnia acting through proposed negative allosteric modulation of GABA(A) receptors. We were interested whether this therapeutic benefit might extend to Parkinson’s disease (PD) patients because GABAergic neurotransmission is implicat...

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Veröffentlicht in:ACS Med Chem Lett
Hauptverfasser: Scott, Peter J. H., Shao, Xia, Desmond, Timothy J., Hockley, Brian G., Sherman, Phillip, Quesada, Carole A., Frey, Kirk A., Koeppe, Robert A., Kilbourn, Michael R., Bohnen, Nicolaas I.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Chemical Society 2016
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4983726/
https://ncbi.nlm.nih.gov/pubmed/27563397
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.5b00435
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