Investigation of Proposed Activity of Clarithromycin at GABA(A) Receptors Using [(11)C]Flumazenil PET

[Image: see text] Clarithromycin is a potential treatment for hypersomnia acting through proposed negative allosteric modulation of GABA(A) receptors. We were interested whether this therapeutic benefit might extend to Parkinson’s disease (PD) patients because GABAergic neurotransmission is implicat...

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Gepubliceerd in:ACS Med Chem Lett
Hoofdauteurs: Scott, Peter J. H., Shao, Xia, Desmond, Timothy J., Hockley, Brian G., Sherman, Phillip, Quesada, Carole A., Frey, Kirk A., Koeppe, Robert A., Kilbourn, Michael R., Bohnen, Nicolaas I.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Chemical Society 2016
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4983726/
https://ncbi.nlm.nih.gov/pubmed/27563397
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.5b00435
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