Investigation of Proposed Activity of Clarithromycin at GABA(A) Receptors Using [(11)C]Flumazenil PET

[Image: see text] Clarithromycin is a potential treatment for hypersomnia acting through proposed negative allosteric modulation of GABA(A) receptors. We were interested whether this therapeutic benefit might extend to Parkinson’s disease (PD) patients because GABAergic neurotransmission is implicat...

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Detalhes bibliográficos
Publicado no:ACS Med Chem Lett
Main Authors: Scott, Peter J. H., Shao, Xia, Desmond, Timothy J., Hockley, Brian G., Sherman, Phillip, Quesada, Carole A., Frey, Kirk A., Koeppe, Robert A., Kilbourn, Michael R., Bohnen, Nicolaas I.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2016
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4983726/
https://ncbi.nlm.nih.gov/pubmed/27563397
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.5b00435
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