Investigation of Proposed Activity of Clarithromycin at GABA(A) Receptors Using [(11)C]Flumazenil PET

[Image: see text] Clarithromycin is a potential treatment for hypersomnia acting through proposed negative allosteric modulation of GABA(A) receptors. We were interested whether this therapeutic benefit might extend to Parkinson’s disease (PD) patients because GABAergic neurotransmission is implicat...

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Publicat a:ACS Med Chem Lett
Autors principals: Scott, Peter J. H., Shao, Xia, Desmond, Timothy J., Hockley, Brian G., Sherman, Phillip, Quesada, Carole A., Frey, Kirk A., Koeppe, Robert A., Kilbourn, Michael R., Bohnen, Nicolaas I.
Format: Artigo
Idioma:Inglês
Publicat: American Chemical Society 2016
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4983726/
https://ncbi.nlm.nih.gov/pubmed/27563397
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.5b00435
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