Tight Junction Protein 1 Modulates Proteasome Capacity and Proteasome Inhibitor Sensitivity in Multiple Myeloma via EGFR/JAK1/STAT3 Signaling

Proteasome inhibitors have revolutionized outcomes in multiple myeloma, but they are used empirically, and primary and secondary resistance are emerging problems. We have identified TJP1 as a determinant of plasma cell proteasome inhibitor susceptibility. TJP1 suppressed expression of the catalytica...

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Udgivet i:Cancer Cell
Main Authors: Zhang, Xing-Ding, Baladandayuthapani, Veerabhadran, Lin, Heather, Mulligan, George, Li, Bin, Esseltine, Dixie-Lee W., Qi, Lin, Xu, Jianliang, Hunziker, Walter, Barlogie, Bart, Usmani, Saad Z., Zhang, Qing, Crowley, John, Hoering, Antje, Shah, Jatin J., Weber, Donna M., Manasanch, Elisabet E., Thomas, Sheeba K., Li, Bing-Zong, Wang, Hui-Han, Zhang, Jiexin, Kuiatse, Isere, Tang, Jin-Le, Wang, Hua, Jin, He, Yang, Jing, Milan, Enrico, Cenci, Simone, Ma, Wen-Cai, Wang, Zhi-Qiang, Davis, Richard Eric, Yang, Lin, Orlowski, Robert Z.
Format: Artigo
Sprog:Inglês
Udgivet: 2016
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4983190/
https://ncbi.nlm.nih.gov/pubmed/27132469
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2016.03.026
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