Elevated interleukin‐27 levels in human neonatal macrophages regulate indoleamine dioxygenase in a STAT‐1 and STAT‐3‐dependent manner

Microbial infections are a major cause of infant mortality as a result of limitations in immune defences. Interleukin‐27 (IL‐27) is a heterodimeric cytokine produced primarily by leucocytes and is immunosuppressive toward lymphocytes and leucocytes. Our laboratory demonstrated that human neonatal ma...

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Publicado en:Immunology
Main Authors: Jung, Joo‐Yong, Gleave Parson, Madeline, Kraft, Jennifer D., Lyda, Logan, Kobe, Brianna, Davis, Celestia, Robinson, Jembber, Peña, Maria Marjorette O., Robinson, Cory M.
Formato: Artigo
Idioma:Inglês
Publicado: John Wiley and Sons Inc. 2016
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Original Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4981608/
https://ncbi.nlm.nih.gov/pubmed/27238498
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/imm.12625
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