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Synergistic Transcriptional Activation of Indoleamine Dioxygenase by IFN-γ and Tumor Necrosis Factor-α
Interferon-γ (IFN-γ)-induced indoleamine 2,3-dioxygenase (IDO) activity inhibits the growth of susceptible intracellular pathogens by catalyzing the oxidative cleavage of the indole ring of l-tryptophan and depleting pools of the essential amino acid. Tumor necrosis factor-α (TNF-α) synergistically...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2003
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1488822/ https://ncbi.nlm.nih.gov/pubmed/13678429 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/107999003322277829 |
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