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Central Role of IFNγ-Indoleamine 2,3 Dioxygenase Axis in Regulation of Interleukin-12-mediated Antitumor Immunity

Sustained intratumoral delivery of IL-12 and GM-CSF induces tumor regression via restoration of tumor-resident CD8+ T-effector/memory cell cytotoxicity and subsequent re-priming of a secondary CD8+ T-effector cell response in tumor-draining lymph nodes (TDLN). However, treatment-induced T-effector a...

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Detalhes bibliográficos
Main Authors: Gu, Tao, Rowswell-Turner, Rachael B., Kilinc, Mehmet O., Egilmez, Nejat K.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2805056/
https://ncbi.nlm.nih.gov/pubmed/20028855
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-09-3170
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