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The Role of IFN-γ and TNF-α-Responsive Regulatory Elements in the Synergistic Induction of Indoleamine Dioxygenase
Indoleamine 2,3-dioxygenase (IDO), which enzymatically depletes tryptophan, is an important antimicrobial defense mechanism against susceptible pathogens. In human epithelial cells, interferon-γ (IFN-γ)-induced IDO expression is transcriptionally enhanced by tumor necrosis factor-α (TNF-α). The purp...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2005
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1488823/ https://ncbi.nlm.nih.gov/pubmed/15684619 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/jir.2005.25.20 |
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