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Synergistic COX2 induction by IFNγ and TNFα self-limits type-1 immunity in the human tumor microenvironment
Maintenance of CTL-, Th1-, and NK cell-mediated type-1 immunity is essential for effective antitumor responses. Unexpectedly, we observed that the critical soluble mediators of type-1 immune effector cells, IFNγ and TNFα, synergize in the induction of cyclooxygenase 2 (COX2), the key enzyme in prost...
Shranjeno v:
| izdano v: | Cancer Immunol Res |
|---|---|
| Main Authors: | , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2016
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4877699/ https://ncbi.nlm.nih.gov/pubmed/26817996 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2326-6066.CIR-15-0157 |
| Oznake: |
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