N-acylhydrazone inhibitors of influenza virus PA endonuclease with versatile metal binding modes

Influenza virus PA endonuclease has recently emerged as an attractive target for the development of novel antiviral therapeutics. This is an enzyme with divalent metal ion(s) (Mg(2+) or Mn(2+)) in its catalytic site: chelation of these metal cofactors is an attractive strategy to inhibit enzymatic a...

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Bibliographic Details
Published in:Sci Rep
Main Authors: Carcelli, Mauro, Rogolino, Dominga, Gatti, Anna, De Luca, Laura, Sechi, Mario, Kumar, Gyanendra, White, Stephen W., Stevaert, Annelies, Naesens, Lieve
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2016
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4980666/
https://ncbi.nlm.nih.gov/pubmed/27510745
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep31500
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