N-acylhydrazone inhibitors of influenza virus PA endonuclease with versatile metal binding modes

Influenza virus PA endonuclease has recently emerged as an attractive target for the development of novel antiviral therapeutics. This is an enzyme with divalent metal ion(s) (Mg(2+) or Mn(2+)) in its catalytic site: chelation of these metal cofactors is an attractive strategy to inhibit enzymatic a...

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Vydáno v:Sci Rep
Hlavní autoři: Carcelli, Mauro, Rogolino, Dominga, Gatti, Anna, De Luca, Laura, Sechi, Mario, Kumar, Gyanendra, White, Stephen W., Stevaert, Annelies, Naesens, Lieve
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2016
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4980666/
https://ncbi.nlm.nih.gov/pubmed/27510745
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep31500
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