N-acylhydrazone inhibitors of influenza virus PA endonuclease with versatile metal binding modes

Influenza virus PA endonuclease has recently emerged as an attractive target for the development of novel antiviral therapeutics. This is an enzyme with divalent metal ion(s) (Mg(2+) or Mn(2+)) in its catalytic site: chelation of these metal cofactors is an attractive strategy to inhibit enzymatic a...

Descrición completa

Gardado en:
Detalles Bibliográficos
Publicado en:Sci Rep
Main Authors: Carcelli, Mauro, Rogolino, Dominga, Gatti, Anna, De Luca, Laura, Sechi, Mario, Kumar, Gyanendra, White, Stephen W., Stevaert, Annelies, Naesens, Lieve
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group 2016
Assuntos:
Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4980666/
https://ncbi.nlm.nih.gov/pubmed/27510745
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep31500
Tags: Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!

Títulos similares