Chelation Motifs Affecting Metal-dependent Viral Enzymes: N′-acylhydrazone Ligands as Dual Target Inhibitors of HIV-1 Integrase and Reverse Transcriptase Ribonuclease H Domain

Human immunodeficiency virus type 1 (HIV-1) infection, still represent a serious global health emergency. The chronic toxicity derived from the current anti-retroviral therapy limits the prolonged use of several antiretroviral agents, continuously requiring the discovery of new antiviral agents with...

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Vydáno v:Front Microbiol
Hlavní autoři: Carcelli, Mauro, Rogolino, Dominga, Gatti, Anna, Pala, Nicolino, Corona, Angela, Caredda, Alessia, Tramontano, Enzo, Pannecouque, Christophe, Naesens, Lieve, Esposito, Francesca
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2017
Témata:
Microbiology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5357622/
https://ncbi.nlm.nih.gov/pubmed/28373864
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fmicb.2017.00440
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