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N-acylhydrazone inhibitors of influenza virus PA endonuclease with versatile metal binding modes
Influenza virus PA endonuclease has recently emerged as an attractive target for the development of novel antiviral therapeutics. This is an enzyme with divalent metal ion(s) (Mg(2+) or Mn(2+)) in its catalytic site: chelation of these metal cofactors is an attractive strategy to inhibit enzymatic a...
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| Опубликовано в: : | Sci Rep |
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| Главные авторы: | , , , , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Nature Publishing Group
2016
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4980666/ https://ncbi.nlm.nih.gov/pubmed/27510745 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep31500 |
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