Phosphorylation of Src by phosphoinositide 3-kinase regulates beta-adrenergic receptor mediated EGFR transactivation

β(2)-adrenergic receptors (β(2)AR) transactivate epidermal growth factor receptors (EGFR) through formation of a β(2)AR-EGFR complex that requires activation of Src to mediate signaling. Here, we show that both lipid and protein kinase activities of the bifunctional phosphoinositide 3-kinase (PI3K)...

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Vydáno v:Cell Signal
Hlavní autoři: Watson, Lewis J., Alexander, Kevin M., Mohan, Maradumane L., Bowman, Amber L., Mangmool, Supachoke, Xiao, Kunhong, Naga Prasad, Sathyamangla V., Rockman, Howard A.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2016
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4980165/
https://ncbi.nlm.nih.gov/pubmed/27169346
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cellsig.2016.05.006
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