Inhibition of protein phosphatase 2A activity by PI3Kγ regulates β-adrenergic receptor function

Phosphoinositide 3-kinaseγ (PI3Kγ) is activated by G-protein coupled receptors (GPCRs). We show here that PI3Kγ inhibits protein phosphatase 2A (PP2A) at the β-adrenergic receptor (βAR, a GPCR) complex altering G-protein coupling. PI3Kγ inhibition results in significant increase of βAR-associated ph...

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Bibliographic Details
Main Authors: Vasudevan, Neelakantan T., Mohan, Maradumane L., Gupta, Manveen K., Hussain, Afshan K., Naga Prasad, Sathyamangla V.
Format: Artigo
Language:Inglês
Published: 2011
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3063893/
https://ncbi.nlm.nih.gov/pubmed/21419339
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2011.02.025
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