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Inhibition of protein phosphatase 2A activity by PI3Kγ regulates β-adrenergic receptor function
Phosphoinositide 3-kinaseγ (PI3Kγ) is activated by G-protein coupled receptors (GPCRs). We show here that PI3Kγ inhibits protein phosphatase 2A (PP2A) at the β-adrenergic receptor (βAR, a GPCR) complex altering G-protein coupling. PI3Kγ inhibition results in significant increase of βAR-associated ph...
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| Hoofdauteurs: | , , , , |
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| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
2011
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3063893/ https://ncbi.nlm.nih.gov/pubmed/21419339 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2011.02.025 |
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