Accelerating Gene Discovery by Phenotyping Whole-Genome Sequenced Multi-mutation Strains and Using the Sequence Kernel Association Test (SKAT)

Forward genetic screens represent powerful, unbiased approaches to uncover novel components in any biological process. Such screens suffer from a major bottleneck, however, namely the cloning of corresponding genes causing the phenotypic variation. Reverse genetic screens have been employed as a way...

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Pubblicato in:PLoS Genet
Autori principali: Timbers, Tiffany A., Garland, Stephanie J., Mohan, Swetha, Flibotte, Stephane, Edgley, Mark, Muncaster, Quintin, Au, Vinci, Li-Leger, Erica, Rosell, Federico I., Cai, Jerry, Rademakers, Suzanne, Jansen, Gert, Moerman, Donald G., Leroux, Michel R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2016
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4980031/
https://ncbi.nlm.nih.gov/pubmed/27508411
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1006235
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