Epitope Mapping of a Monoclonal Antibody Directed against Neisserial Heparin Binding Antigen Using Next Generation Sequencing of Antigen-Specific Libraries

We explore here the potential of a newly described technology, which is named PROFILER and is based on next generation sequencing of gene-specific lambda phage-displayed libraries, to rapidly and accurately map monoclonal antibody (mAb) epitopes. For this purpose, we used a novel mAb (designated 31E...

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Опубликовано в: :PLoS One
Главные авторы: Domina, Maria, Lanza Cariccio, Veronica, Benfatto, Salvatore, Venza, Mario, Venza, Isabella, Donnarumma, Danilo, Bartolini, Erika, Borgogni, Erica, Bruttini, Marco, Santini, Laura, Midiri, Angelina, Galbo, Roberta, Romeo, Letizia, Patanè, Francesco, Biondo, Carmelo, Norais, Nathalie, Masignani, Vega, Teti, Giuseppe, Felici, Franco, Beninati, Concetta
Формат: Artigo
Язык:Inglês
Опубликовано: Public Library of Science 2016
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Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4980009/
https://ncbi.nlm.nih.gov/pubmed/27508302
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0160702
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