Epitope Mapping of a Monoclonal Antibody Directed against Neisserial Heparin Binding Antigen Using Next Generation Sequencing of Antigen-Specific Libraries

We explore here the potential of a newly described technology, which is named PROFILER and is based on next generation sequencing of gene-specific lambda phage-displayed libraries, to rapidly and accurately map monoclonal antibody (mAb) epitopes. For this purpose, we used a novel mAb (designated 31E...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Domina, Maria, Lanza Cariccio, Veronica, Benfatto, Salvatore, Venza, Mario, Venza, Isabella, Donnarumma, Danilo, Bartolini, Erika, Borgogni, Erica, Bruttini, Marco, Santini, Laura, Midiri, Angelina, Galbo, Roberta, Romeo, Letizia, Patanè, Francesco, Biondo, Carmelo, Norais, Nathalie, Masignani, Vega, Teti, Giuseppe, Felici, Franco, Beninati, Concetta
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4980009/
https://ncbi.nlm.nih.gov/pubmed/27508302
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0160702
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