Hybrid inhibitor of peripheral cannabinoid-1 receptors and inducible nitric oxide synthase mitigates liver fibrosis

Liver fibrosis, a consequence of chronic liver injury and a way station to cirrhosis and hepatocellular carcinoma, lacks effective treatment. Endocannabinoids acting via cannabinoid-1 receptors (CB(1)R) induce profibrotic gene expression and promote pathologies that predispose to liver fibrosis. CB(...

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Vydáno v:JCI Insight
Hlavní autoři: Cinar, Resat, Iyer, Malliga R., Liu, Ziyi, Cao, Zongxian, Jourdan, Tony, Erdelyi, Katalin, Godlewski, Grzegorz, Szanda, Gergő, Liu, Jie, Park, Joshua K., Mukhopadhyay, Bani, Rosenberg, Avi Z., Liow, Jeih-San, Lorenz, Robin G., Pacher, Pal, Innis, Robert B., Kunos, George
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Clinical Investigation 2016
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4979564/
https://ncbi.nlm.nih.gov/pubmed/27525312
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.87336
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