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Human pregnane X receptor compromises the function of p53 and promotes malignant transformation

The pregnane X receptor (PXR) is well established as a nuclear receptor that has a central role in xenobiotic metabolism and disposition. However, emerging evidence suggests that PXR is also a regulator of apoptosis, promoting a malignant phenotype both in vitro and in vivo. The tumor suppressor p53...

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Bibliografiske detaljer
Udgivet i:Cell Death Discov
Main Authors: Robbins, D, Cherian, M, Wu, J, Chen, T
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2016
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4979430/
https://ncbi.nlm.nih.gov/pubmed/27547448
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddiscovery.2016.23
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