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Human pregnane X receptor compromises the function of p53 and promotes malignant transformation
The pregnane X receptor (PXR) is well established as a nuclear receptor that has a central role in xenobiotic metabolism and disposition. However, emerging evidence suggests that PXR is also a regulator of apoptosis, promoting a malignant phenotype both in vitro and in vivo. The tumor suppressor p53...
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| Publicado no: | Cell Death Discov |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4979430/ https://ncbi.nlm.nih.gov/pubmed/27547448 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddiscovery.2016.23 |
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