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Tryptophan 299 is a conserved residue of human pregnane X receptor critical for the functional consequence of ligand binding
PXR is a xenobiotic receptor that regulates drug metabolism by regulating the expression of drug-metabolizing enzymes including CYP3A4. It can be modulated by chemicals with different structures, functional groups and sizes. X-ray crystal structures of the ligand binding domain of human PXR (hPXR) a...
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| Foilsithe in: | Biochem Pharmacol |
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| Main Authors: | , , , , |
| Formáid: | Artigo |
| Teanga: | Inglês |
| Foilsithe: |
2016
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| Ábhair: | |
| Rochtain Ar Líne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4778391/ https://ncbi.nlm.nih.gov/pubmed/26902414 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2016.02.009 |
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