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Design Considerations for Dose-Expansion Cohorts in Phase I Trials
Phase I trials are increasingly including dose-expansion cohorts after the maximum-tolerated dose (MTD) has been reached to better characterize the toxicity profile or identify early signs of efficacy within a specific disease population. This article provides guidelines on how to monitor safety and...
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| Publicado no: | J Clin Oncol |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society of Clinical Oncology
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4979131/ https://ncbi.nlm.nih.gov/pubmed/24101039 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/JCO.2012.47.9949 |
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