Wnt5a Signals through DVL1 to Repress Ribosomal DNA Transcription by RNA Polymerase I

Ribosome biogenesis is essential for cell growth and proliferation and is commonly elevated in cancer. Accordingly, numerous oncogene and tumor suppressor signaling pathways target rRNA synthesis. In breast cancer, non-canonical Wnt signaling by Wnt5a has been reported to antagonize tumor growth. He...

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Publicado en:PLoS Genet
Autores principales: Dass, Randall A., Sarshad, Aishe A., Carson, Brittany B., Feenstra, Jennifer M., Kaur, Amanpreet, Obrdlik, Ales, Parks, Matthew M., Prakash, Varsha, Love, Damon K., Pietras, Kristian, Serra, Rosa, Blanchard, Scott C., Percipalle, Piergiorgio, Brown, Anthony M. C., Vincent, C. Theresa
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4976976/
https://ncbi.nlm.nih.gov/pubmed/27500936
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1006217
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