Glycogen Synthase Kinase (GSK) 3β Phosphorylates and Protects Nuclear Myosin 1c from Proteasome-Mediated Degradation to Activate rDNA Transcription in Early G1 Cells

Nuclear myosin 1c (NM1) mediates RNA polymerase I (pol I) transcription activation and cell cycle progression by facilitating PCAF-mediated H3K9 acetylation, but the molecular mechanism by which NM1 is regulated remains unclear. Here, we report that at early G1 the glycogen synthase kinase (GSK) 3β...

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Detalhes bibliográficos
Main Authors: Sarshad, Aishe A., Corcoran, Martin, Al-Muzzaini, Bader, Borgonovo-Brandter, Laura, Von Euler, Anne, Lamont, Douglas, Visa, Neus, Percipalle, Piergiorgio
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4046919/
https://ncbi.nlm.nih.gov/pubmed/24901984
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1004390
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