MRF4 negatively regulates adult skeletal muscle growth by repressing MEF2 activity

The myogenic regulatory factor MRF4 is highly expressed in adult skeletal muscle but its function is unknown. Here we show that Mrf4 knockdown in adult muscle induces hypertrophy and prevents denervation-induced atrophy. This effect is accompanied by increased protein synthesis and widespread activa...

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Veröffentlicht in:Nat Commun
Hauptverfasser: Moretti, Irene, Ciciliot, Stefano, Dyar, Kenneth A., Abraham, Reimar, Murgia, Marta, Agatea, Lisa, Akimoto, Takayuki, Bicciato, Silvio, Forcato, Mattia, Pierre, Philippe, Uhlenhaut, N. Henriette, Rigby, Peter W. J., Carvajal, Jaime J., Blaauw, Bert, Calabria, Elisa, Schiaffino, Stefano
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4976255/
https://ncbi.nlm.nih.gov/pubmed/27484840
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms12397
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