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MRF4 negatively regulates adult skeletal muscle growth by repressing MEF2 activity
The myogenic regulatory factor MRF4 is highly expressed in adult skeletal muscle but its function is unknown. Here we show that Mrf4 knockdown in adult muscle induces hypertrophy and prevents denervation-induced atrophy. This effect is accompanied by increased protein synthesis and widespread activa...
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| Vydáno v: | Nat Commun |
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| Hlavní autoři: | , , , , , , , , , , , , , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
Nature Publishing Group
2016
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4976255/ https://ncbi.nlm.nih.gov/pubmed/27484840 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms12397 |
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