Egg antigen p40 of Schistosoma japonicum promotes senescence in activated hepatic stellate cells by activation of the STAT3/p53/p21 pathway

Liver fibrosis is a serious disease that is characterized by the excess deposition of extracellular matrix (ECM) components. Activated hepatic stellate cells (HSCs) are a major source of ECM and serve as a key regulator in liver fibrogenesis. Inactivation of HSCs is essential for liver fibrotic regr...

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Detalhes bibliográficos
Publicado no:Cell Death Dis
Main Authors: Chen, Jinling, Xu, Tianhua, Zhu, Dandan, Wang, Jianxin, Huang, Caiqun, Lyu, Lei, Hu, Bin, Sun, Wei, Duan, Yinong
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4973363/
https://ncbi.nlm.nih.gov/pubmed/27468691
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2016.228
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