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Soluble egg antigens of Schistosoma japonicum induce senescence in activated hepatic stellate cells by activation of the STAT3/p53/p21 pathway

Liver fibrosis is characterized by the activation of hepatic stellate cells (HSCs). Recent findings suggest that senescence of activated HSCs might limit the development of liver fibrosis. Based on previously observed anti-fibrotic effects of soluble egg antigens from Schistosoma japonicum in vitro,...

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Bibliografiske detaljer
Udgivet i:Sci Rep
Main Authors: Chen, Jinling, Pan, Jing, Wang, Jianxin, Song, Ke, Zhu, Dandan, Huang, Caiqun, Duan, Yinong
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2016
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4973244/
https://ncbi.nlm.nih.gov/pubmed/27489164
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep30957
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