Schistosoma japonicum Soluble Egg Antigens Facilitate Hepatic Stellate Cell Apoptosis by Downregulating Akt Expression and Upregulating p53 and DR5 Expression

BACKGROUND: The induction of hepatic stellate cell (HSC) apoptosis has potential as a potent strategy to diminish the progression of liver fibrosis. Previous studies have demonstrated the ability of soluble egg antigens (SEA) from schistosomes to inhibit HSC activation and to induce apoptosis in vit...

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Détails bibliographiques
Auteurs principaux: Wang, Jianxin, Xu, Feifan, Zhu, Dandan, Duan, Yinong, Chen, Jinling, Sun, Xiaolei, He, Xue, Li, Pan, Sun, Wei, Feng, Jinrong
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2014
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4140669/
https://ncbi.nlm.nih.gov/pubmed/25144704
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pntd.0003106
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