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Schistosoma japonicum Soluble Egg Antigens Facilitate Hepatic Stellate Cell Apoptosis by Downregulating Akt Expression and Upregulating p53 and DR5 Expression

BACKGROUND: The induction of hepatic stellate cell (HSC) apoptosis has potential as a potent strategy to diminish the progression of liver fibrosis. Previous studies have demonstrated the ability of soluble egg antigens (SEA) from schistosomes to inhibit HSC activation and to induce apoptosis in vit...

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書誌詳細
主要な著者: Wang, Jianxin, Xu, Feifan, Zhu, Dandan, Duan, Yinong, Chen, Jinling, Sun, Xiaolei, He, Xue, Li, Pan, Sun, Wei, Feng, Jinrong
フォーマット: Artigo
言語:Inglês
出版事項: Public Library of Science 2014
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4140669/
https://ncbi.nlm.nih.gov/pubmed/25144704
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pntd.0003106
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