Genomic copy number dictates a gene-independent cell response to CRISPR-Cas9 targeting

The CRISPR-Cas9 system enables genome editing and somatic cell genetic screens in mammalian cells. We performed genome scale loss-of-function screens in 33 cancer cell lines to identify genes essential for proliferation/survival and found a strong correlation between increased gene copy number and d...

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Bibliografiset tiedot
Julkaisussa:Cancer Discov
Päätekijät: Aguirre, Andrew J., Meyers, Robin M., Weir, Barbara A., Vazquez, Francisca, Zhang, Cheng-Zhong, Ben-David, Uri, Cook, April, Ha, Gavin, Harrington, William F., Doshi, Mihir B., Kost-Alimova, Maria, Gill, Stanley, Xu, Han, Ali, Levi D., Jiang, Guozhi, Pantel, Sasha, Lee, Yenarae, Goodale, Amy, Cherniack, Andrew D., Oh, Coyin, Kryukov, Gregory, Cowley, Glenn S., Garraway, Levi A., Stegmaier, Kimberly, Roberts, Charles W., Golub, Todd R., Meyerson, Matthew, Root, David E., Tsherniak, Aviad, Hahn, William C.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2016
Aiheet:
Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4972686/
https://ncbi.nlm.nih.gov/pubmed/27260156
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-16-0154
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