Genetic modifiers of EGFR dependence in non-small cell lung cancer

Lung adenocarcinomas harboring activating mutations in the epidermal growth factor receptor (EGFR) represent a common molecular subset of non-small cell lung cancer (NSCLC) cases. EGFR mutations predict sensitivity to EGFR tyrosine kinase inhibitors (TKIs) and thus represent a dependency in NSCLCs h...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Sharifnia, Tanaz, Rusu, Victor, Piccioni, Federica, Bagul, Mukta, Imielinski, Marcin, Cherniack, Andrew D., Pedamallu, Chandra Sekhar, Wong, Bang, Wilson, Frederick H., Garraway, Levi A., Altshuler, David, Golub, Todd R., Root, David E., Subramanian, Aravind, Meyerson, Matthew
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2014
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4284598/
https://ncbi.nlm.nih.gov/pubmed/25512530
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1412228112
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