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Resistance to EGFR blockade in colorectal cancer: liquid biopsies and latent subclones

Two recent papers identify KRAS activation as a mechanism of acquired resistance to EGFR blockade in colorectal cancer. In doing so, they suggest that resistance to single-agent EGFR blockade will be unavoidable because these alterations exist as latent subclones within the tumor even prior to the i...

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Détails bibliographiques
Auteurs principaux: Konieczkowski, David J, Garraway, Levi A
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group 2013
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3541651/
https://ncbi.nlm.nih.gov/pubmed/22847744
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cr.2012.115
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