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Resistance to EGFR blockade in colorectal cancer: liquid biopsies and latent subclones
Two recent papers identify KRAS activation as a mechanism of acquired resistance to EGFR blockade in colorectal cancer. In doing so, they suggest that resistance to single-agent EGFR blockade will be unavoidable because these alterations exist as latent subclones within the tumor even prior to the i...
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| Main Authors: | , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Nature Publishing Group
2013
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3541651/ https://ncbi.nlm.nih.gov/pubmed/22847744 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cr.2012.115 |
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