The molecular evolution of acquired resistance to targeted EGFR blockade in colorectal cancers

Colorectal tumors that are wild-type (WT) for KRAS are often sensitive to EGFR blockade, but almost always develop resistance within several months of initiating therapy(1,2). The mechanisms underlying this acquired resistance to anti-EGFR antibodies are largely unknown. This situation stands in mar...

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Detalhes bibliográficos
Main Authors: Diaz, Luis A., Williams, Richard, Wu, Jian, Kinde, Isaac, Hecht, J. Randolph, Berlin, Jordan, Allen, Benjamin, Bozic, Ivana, Reiter, Johannes G., Nowak, Martin A., Kinzler, Kenneth W., Oliner, Kelly S., Vogelstein, Bert
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3436069/
https://ncbi.nlm.nih.gov/pubmed/22722843
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature11219
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