Combined blockade of EGFR and glutamine metabolism in preclinical models of colorectal cancer

Improving response to epidermal growth factor receptor (EGFR)-targeted therapies in patients with advanced wild-type (WT) RAS colorectal cancer (CRC) remains an unmet need. In this preclinical work, we evaluated a new therapeutic combination aimed at enhancing efficacy by targeting cancer cell metab...

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Detalhes bibliográficos
Publicado no:Transl Oncol
Main Authors: Cohen, Allison S., Geng, Ling, Zhao, Ping, Fu, Allie, Schulte, Michael L., Graves-Deal, Ramona, Washington, M. Kay, Berlin, Jordan, Coffey, Robert J., Manning, H. Charles
Formato: Artigo
Idioma:Inglês
Publicado em: Neoplasia Press 2020
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Original article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7348062/
https://ncbi.nlm.nih.gov/pubmed/32652471
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tranon.2020.100828
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