The molecular evolution of acquired resistance to targeted EGFR blockade in colorectal cancers

Colorectal tumors that are wild-type (WT) for KRAS are often sensitive to EGFR blockade, but almost always develop resistance within several months of initiating therapy(1,2). The mechanisms underlying this acquired resistance to anti-EGFR antibodies are largely unknown. This situation stands in mar...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Main Authors: Diaz, Luis A., Williams, Richard, Wu, Jian, Kinde, Isaac, Hecht, J. Randolph, Berlin, Jordan, Allen, Benjamin, Bozic, Ivana, Reiter, Johannes G., Nowak, Martin A., Kinzler, Kenneth W., Oliner, Kelly S., Vogelstein, Bert
Format: Artigo
Sprog:Inglês
Udgivet: 2012
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3436069/
https://ncbi.nlm.nih.gov/pubmed/22722843
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature11219
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker