Genomic copy number dictates a gene-independent cell response to CRISPR-Cas9 targeting

The CRISPR-Cas9 system enables genome editing and somatic cell genetic screens in mammalian cells. We performed genome scale loss-of-function screens in 33 cancer cell lines to identify genes essential for proliferation/survival and found a strong correlation between increased gene copy number and d...

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Publicat a:Cancer Discov
Autors principals: Aguirre, Andrew J., Meyers, Robin M., Weir, Barbara A., Vazquez, Francisca, Zhang, Cheng-Zhong, Ben-David, Uri, Cook, April, Ha, Gavin, Harrington, William F., Doshi, Mihir B., Kost-Alimova, Maria, Gill, Stanley, Xu, Han, Ali, Levi D., Jiang, Guozhi, Pantel, Sasha, Lee, Yenarae, Goodale, Amy, Cherniack, Andrew D., Oh, Coyin, Kryukov, Gregory, Cowley, Glenn S., Garraway, Levi A., Stegmaier, Kimberly, Roberts, Charles W., Golub, Todd R., Meyerson, Matthew, Root, David E., Tsherniak, Aviad, Hahn, William C.
Format: Artigo
Idioma:Inglês
Publicat: 2016
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4972686/
https://ncbi.nlm.nih.gov/pubmed/27260156
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-16-0154
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