Obesity-induced inflammation and desmoplasia promote pancreatic cancer progression and resistance to chemotherapy

It remains unclear how obesity worsens treatment outcomes in patients with pancreatic ductal adenocarcinoma (PDAC). In normal pancreas, obesity promotes inflammation and fibrosis. We found in mouse models of PDAC that obesity also promotes desmoplasia associated with accelerated tumor growth and imp...

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Publicado en:Cancer Discov
Main Authors: Incio, Joao, Liu, Hao, Suboj, Priya, Chin, Shan M., Chen, Ivy X., Pinter, Matthias, Ng, Mei R., Nia, Hadi T., Grahovac, Jelena, Kao, Shannon, Babykutty, Suboj, Huang, Yuhui, Jung, Keehoon, Rahbari, Nuh N., Han, Xiaoxing, Chauhan, Vikash P., Martin, John D., Kahn, Julia, Huang, Peigen, Desphande, Vikram, Michaelson, James, Michelakos, Theodoros P., Ferrone, Cristina R., Soares, Raquel, Boucher, Yves, Fukumura, Dai, Jain, Rakesh K.
Formato: Artigo
Idioma:Inglês
Publicado: 2016
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4972679/
https://ncbi.nlm.nih.gov/pubmed/27246539
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-15-1177
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