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Obesity-induced inflammation and desmoplasia promote pancreatic cancer progression and resistance to chemotherapy

It remains unclear how obesity worsens treatment outcomes in patients with pancreatic ductal adenocarcinoma (PDAC). In normal pancreas, obesity promotes inflammation and fibrosis. We found in mouse models of PDAC that obesity also promotes desmoplasia associated with accelerated tumor growth and imp...

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Vydáno v:Cancer Discov
Hlavní autoři: Incio, Joao, Liu, Hao, Suboj, Priya, Chin, Shan M., Chen, Ivy X., Pinter, Matthias, Ng, Mei R., Nia, Hadi T., Grahovac, Jelena, Kao, Shannon, Babykutty, Suboj, Huang, Yuhui, Jung, Keehoon, Rahbari, Nuh N., Han, Xiaoxing, Chauhan, Vikash P., Martin, John D., Kahn, Julia, Huang, Peigen, Desphande, Vikram, Michaelson, James, Michelakos, Theodoros P., Ferrone, Cristina R., Soares, Raquel, Boucher, Yves, Fukumura, Dai, Jain, Rakesh K.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2016
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4972679/
https://ncbi.nlm.nih.gov/pubmed/27246539
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-15-1177
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