Structure-Based Drug Discovery for Prion Disease Using a Novel Binding Simulation

The accumulation of abnormal prion protein (PrP(Sc)) converted from the normal cellular isoform of PrP (PrP(C)) is assumed to induce pathogenesis in prion diseases. Therefore, drug discovery studies for these diseases have focused on the protein conversion process. We used a structure-based drug dis...

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Bibliografische gegevens
Gepubliceerd in:EBioMedicine
Hoofdauteurs: Ishibashi, Daisuke, Nakagaki, Takehiro, Ishikawa, Takeshi, Atarashi, Ryuichiro, Watanabe, Ken, Cruz, Felipe A., Hamada, Tsuyoshi, Nishida, Noriyuki
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Elsevier 2016
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Research Paper
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4972544/
https://ncbi.nlm.nih.gov/pubmed/27333028
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2016.06.010
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