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Increased expression of p62/SQSTM1 in prion diseases and its association with pathogenic prion protein
Prion diseases are neurodegenerative disorders characterized by the aggregation of abnormally folded prion protein (PrP(Sc)). In this study, we focused on the mechanism of clearance of PrP(Sc), which remains unclear. p62 is a cytosolic protein known to mediate both the formation and degradation of a...
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| Główni autorzy: | , , , , , , |
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| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
Nature Publishing Group
2014
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| Hasła przedmiotowe: | |
| Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3968452/ https://ncbi.nlm.nih.gov/pubmed/24675871 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep04504 |
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