Thermostability of Well-Ordered HIV Spikes Correlates with the Elicitation of Autologous Tier 2 Neutralizing Antibodies

In the context of HIV vaccine design and development, HIV-1 spike mimetics displaying a range of stabilities were evaluated to determine whether more stable, well-ordered trimers would more efficiently elicit neutralizing antibodies. To begin, in vitro analysis of trimers derived from the cysteine-s...

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Detalhes bibliográficos
Publicado no:PLoS Pathog
Main Authors: Feng, Yu, Tran, Karen, Bale, Shridhar, Kumar, Shailendra, Guenaga, Javier, Wilson, Richard, de Val, Natalia, Arendt, Heather, DeStefano, Joanne, Ward, Andrew B., Wyatt, Richard T.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4972253/
https://ncbi.nlm.nih.gov/pubmed/27487086
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1005767
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