Pharmacokinetic/pharmacodynamic modelling of the antimalarial effect of Actelion‐451840 in an induced blood stage malaria study in healthy subjects

AIMS: The aim of this study was to use data from an experimental induced blood stage malaria clinical trial to characterize the antimalarial activity of the new compound Actelion‐451840 using pharmacokinetic/pharmacodynamic (PK/PD) modelling. Then, using simulations from the model, the dose and dosi...

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Bibliographic Details
Published in:Br J Clin Pharmacol
Main Authors: Krause, Andreas, Dingemanse, Jasper, Mathis, Alexandre, Marquart, Louise, Möhrle, Jörg J., McCarthy, James S.
Format: Artigo
Language:Inglês
Published: John Wiley and Sons Inc. 2016
Subjects:
Pharmacokinetic Dynamic Relationships
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4972157/
https://ncbi.nlm.nih.gov/pubmed/27062080
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.12962
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