Retrospective Analysis Using Pharmacokinetic/Pharmacodynamic Modeling and Simulation Offers Improvements in Efficiency of the Design of Volunteer Infection Studies for Antimalarial Drug Development

Volunteer infection studies using the induced blood stage malaria (IBSM) model have been shown to facilitate antimalarial drug development. Such studies have traditionally been undertaken in single‐dose cohorts, as many as necessary to obtain the dose‐response relationship. To enhance ethical and lo...

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Bibliografski detalji
Izdano u:Clin Transl Sci
Glavni autori: Andrews, Kayla Ann, Owen, Joel S., McCarthy, James, Wesche, David, Gobeau, Nathalie, Grasela, Thaddeus H., Möhrle, Jörg J.
Format: Artigo
Jezik:Inglês
Izdano: John Wiley and Sons Inc. 2020
Teme:
Research
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7993277/
https://ncbi.nlm.nih.gov/pubmed/33326705
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cts.12934
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