Semimechanistic Pharmacokinetic and Pharmacodynamic Modeling of Piperaquine in a Volunteer Infection Study with Plasmodium falciparum Blood-Stage Malaria

Dihydroartemisinin-piperaquine is a recommended first-line artemisinin combination therapy for Plasmodium falciparum malaria. Piperaquine is also under consideration for other antimalarial combination therapies. The aim of this study was to develop a pharmacokinetic-pharmacodynamic model that might...

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Udgivet i:Antimicrob Agents Chemother
Main Authors: Wattanakul, Thanaporn, Baker, Mark, Mohrle, Joerg, McWhinney, Brett, Hoglund, Richard M., McCarthy, James S., Tarning, Joel
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2021
Fag:
Pharmacology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8097471/
https://ncbi.nlm.nih.gov/pubmed/33468477
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01583-20
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