First-in-Humans Study of the Safety, Tolerability, and Pharmacokinetics of ACT-451840, a New Chemical Entity with Antimalarial Activity

Emerging resistance to antimalarial agents raises the need for new drugs. ACT-451840 is a new compound with potent activity against sensitive and resistant Plasmodium falciparum strains. This was a first-in-humans single-ascending-dose study to investigate the safety, tolerability, and pharmacokinet...

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Publicat a:Antimicrob Agents Chemother
Autors principals: Bruderer, Shirin, Hurst, Noémie, de Kanter, Ruben, Miraval, Tommaso, Pfeifer, Thomas, Donazzolo, Yves, Dingemanse, Jasper
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2015
Matèries:
Pharmacology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4335896/
https://ncbi.nlm.nih.gov/pubmed/25421475
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.04125-14
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