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Tumor responsiveness to statins requires overexpression of the ARF6 pathway

The mevalonate pathway results in the prenylation of small GTPases, which are pivotal for oncogenesis and cancer malignancies. However, inhibitors of this pathway, such as statins, have not necessarily produced favorable results in clinical trials. We recently identified properties of statin respond...

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Bibliografski detalji
Izdano u:Mol Cell Oncol
Glavni autori: Sabe, Hisataka, Hashimoto, Ari, Hashimoto, Shigeru, Oikawa, Tsukasa
Format: Artigo
Jezik:Inglês
Izdano: Taylor & Francis 2016
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Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4972113/
https://ncbi.nlm.nih.gov/pubmed/27652329
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/23723556.2016.1185564
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