The EGFR-GEP100-Arf6 pathway in breast cancer: Full invasiveness is not from the inside

Arf6 and its effector AMAP1 are overexpressed in malignant breast cancer cells, and are involved in their invasion and metastasis. We recently revealed that GEP100, a guanine nucleotide exchanging factor, is responsible for the activation of Arf6 which induces invasion and metastasis. GEP100 associa...

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Autors principals: Sabe, Hisataka, Hashimoto, Shigeru, Morishige, Masaki, Hashimoto, Ari, Ogawa, Eiji
Format: Artigo
Idioma:Inglês
Publicat: Landes Bioscience 2008
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2634987/
https://ncbi.nlm.nih.gov/pubmed/19262097
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